AZOLES MNEMONICS
Azole antifungal agents prevent the synthesis of ergosterol, a major component of fungal plasma membranes, by inhibiting the cytochrome P-450-dependent enzyme lanosterol demethylase (also referred to as 14α-sterol demethylase or P-450DM). This enzyme also plays an important role in cholesterol synthesis in mammals. Exposure of fungi to an azole causes depletion of ergosterol and accumulation …