Meltzer’s Triad

Meltzer Triad

Meltzer’s triad describes the classical symptoms suggesting the diagnosis of cryoglobulinaemia of polyclonal CGs seen in essential-, viral-, or connective tissue disease-associated cryoglobulinaemia. The triad consists of:

  • palpable purpura
  • arthralgia (joint pain)
  • weakness.

Do note that Meltzer’s triad typically occurs in Type 2 and Type 3 Cryoglobulinemia ie Mixed Cryoglobulinemia.

The classic presentation of mixed (types II and III) cryoglobulinaemia is characterized by triad of recurrent showers of dependent palpable purpura, asthenia, and arthritis or arthralgia.

Remember the Meltzer triad using the mnemonic MAP – Myalgia, Arthralgias, Purpura.



Do read about other triads in medicine here.

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