RATE LIMITING ENZYMES OF METABOLIC REACTIONS

Rate limiting enzymes are one of the most frequently encountered Biochemistry one-liners or direct MCQs in NEET-PG and other PG entrance exams.
Rate limiting enzymes are also an important topic for medical school exams.

You must know the rate limiting enzymes of all the important biochemical reactions as well as the substrate and product for that step.
Use this list for a rapid revision of all Rate limiting enzymes.

SR NUMMETABOLIC REACTIONRATE LIMITING ENZYMES
1Glycogenesis Glycogen synthetase
2glycogenolysisPhosphorylase
3GlycolysisPhosphofructokinase-1 (PFK-1)
4GluconeogenesisPhosphoenolpyruvate carboxykinase
5Fatty acid synthesisAcetyl CoA carboxylase
6Cholestrol synthesisHMG CoA reductase
7Bile acid synthesis 7-alpha- hydroxylase
8Urea synthesis carbonyl phosphate synthetase, ornithine transcarbonylase
9porphyrin synthesisD- aminolevulinate synthetase
10Uric acid synthesis Xanthine oxidase
11Purine biosynthesisPhosphoribosyl prophosphate synthetase
12HMP shuntGlucose-6-Phosphate dehydrogenase
13TCA cycleIsocitrate dehydrogenase
14Fatty acid oxidationCarnitine acyltransferase-1

That list seems complete, doesn’t it ?
Do let us know in the comments below, if we missed any reaction and its rate limiting enzyme.

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