We have two good mnemonics for properties of Sulfonamides and their clinical side effects.
Remember the mnemonic SULFA for the basic characteristics as well as side effects of sulphonamides.
Basic characteristics (remember SULFA):
Solubility low
Useful for Urinary tract infections
Large spectrum (active against gram positive and gram negative
bacteria)
Folic acid synthesis blocker ( DHPS inhibitor)
Antimetabolite /Analog of PABA
Side effects of Sulfonamides include (remember SULFA):
Steven-Johnson syndrome / Skin rashes
Urticaria / Urine precipitation (crystalluria)
Leucopenia
Folic acid deficency
Aplastic Anemia
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